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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

cortical cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Akt (1) Apoptosis (2) Aryl Hydrocarbon Receptor (1) Bcl-2 Family (1) Calcium Channel (1) COX (1) Dopamine Receptor (1) GABA Receptor (1) iGluR (2) Interleukin Related (2) MDM-2/p53 (1) mGluR (2) mTOR (1) Neurokinin Receptor (1) NO Synthase (2) PARP (1) PERK (1) Reactive Oxygen Species (1) Sigma Receptor (1) Sodium Channel (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Inflammation/Immunology (3) Neurological Disease (16)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: Nuclear Factor of activated T Cells (NFAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123076

Pifithrin-α, p-Nitro, Cyclic 3 Publications Verification PFN-α	MDM-2/p53	Neurological Disease
Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED₅₀=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue .

HY-100834

5,7-Dichlorokynurenic acid 5,7-DCKA
5,7-Dichlorokynurenic acid (5,7-DCKA) is a selective and competitive antagonist of the glycine site on NMDA receptor with a K_B of 65 nM. 5,7-Dichlorokynurenic acid, a derivative of kynurenic acid, reduced NMDA-induced neuron injury in rat cortical cell cultures .

HY-100547

IEM-1754
IEM-1754, a dicationic adamantane derivative, is a potent blocker of open channels of native ionotropic glutamate receptors including quisqualate-sensitive receptors in insect muscles, NMDAR in cultured rat cortical neurons, and AMPAR in freshly isolated hippocampal cells. IEM-1754 shows anticonvulsant potency in vivo .

HY-N3117

Paeonilactone B (+)-Paeonilactone B	Others	Neurological Disease
Paeonilactone B is a monoterpene with neuroprotective effect against oxidative stress. Paeonilactone B protects rat cortical cells against H₂O₂-induced neurotoxicity .

HY-N11930

5-Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone	Others	Neurological Disease
Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone is a neuroprotective agent . Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone shows significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cell .

HY-118482

Sauristolactam Saurolactam	Others	Neurological Disease
Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus chinensis, has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells . Sauristolactam also inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation .

HY-100834A

5,7-Dichlorokynurenic acid sodium 5,7-DCKA sodium	iGluR	Neurological Disease
5,7-Dichlorokynurenic acid (sodium) is the sodium form of 5,7-Dichlorokynurenic acid (HY-100834). 5,7-Dichlorokynurenic acid is a selective and competitive antagonist of the glycine site on the NMDA receptor with a K_B of 65 nM. 5,7-Dichlorokynurenic acid, a derivative of kynurenic acid, reduces NMDA-induced neuron injury in rat cortical cell cultures .

HY-120079

MSN-125 1 Publications Verification	Bcl-2 Family Apoptosis	Cancer
MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC₅₀ of 4 μM. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity .

HY-P2475

[Pro9]-Substance P

Neurokinin Receptor Neurological Disease

[Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC₅₀ of 0.93 nM .

[Pro9]-Substance P	Neurokinin Receptor	Neurological Disease
[Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC₅₀ of 0.93 nM .

HY-102064

SR 57227A 1 Publications Verification	5-HT Receptor	Neurological Disease
SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC₅₀) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects .

HY-N8572

3',4'-Dimethoxyflavone	PARP Reactive Oxygen Species Aryl Hydrocarbon Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects .

HY-18100A

PRE-084 hydrochloride Maximum Cited Publications 7 Publications Verification	Sigma Receptor Akt NO Synthase	Cardiovascular Disease Neurological Disease
PRE-084 hydrochloride is a highly selective σ1 receptor (S1R) agonist, with an IC₅₀ of 44 nM. PRE-084 hydrochloride exhibits good neuroprotective effects, can improve motor function and motor neuron survival in mice. PRE-084 hydrochloride also can ameliorate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway .

HY-100769

Hypidone hydrochloride 1 Publications Verification YL0919	5-HT Receptor	Neurological Disease
Hypidone hydrochloride (YL0919) is an orally active antidepressant agent with dual activity as a highly seletive 5-HT uptake blocker and an effective 5-HT_1A receptor agonist (K_i=0.19 nM). Hypidone hydrochloride inhibits the uptake of [ ³H]-5-HT into rat cerebral cortical synaptosomes and HEK293 cells with IC₅₀s of 1.78 nM and 1.93 nM, respectively. Hypidone hydrochloride shows remarkable antidepressant effects in animal models and has the poential for the investigation of depressive disorder .

HY-109046

Tulrampator 1 Publications Verification CX-1632; S-47445	iGluR mTOR	Neurological Disease
Tulrampator (S-47445) is an orally active selective AMPA receptor modulator. Tulrampator possesses procognitive, enhancing synaptic plasticity, anti-depressant-anxiolytic-like, procognitive and potential neuroprotective properties. Tulrampator can be used for research of alzheimer’s disease and in major depressive disorder .

HY-103502

CGP7930	GABA Receptor	Neurological Disease
CGP7930 (3-(3’,5’-Di-tert-butyl-4’-hydroxy) phenyl-2, 2-dimethylpropanol) is a positive metabotropic GABAB receptor allosteric modulator. CGP7930 enhances the inhibitory effect of l-baclofen on the oscillatory activity of cultured cortical neurons .

HY-N0123

Aloin Maximum Cited Publications 7 Publications Verification Aloin-A; Barbaloin-A	Others	Cancer
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) .

HY-141832

mGluR5 modulator 1	mGluR	Neurological Disease
mGluR5 modulator 1 is a mGluR5 positive allosteric modulator. mGluR5 modulator 1 can be used for the research of the schizophrenia and cognitive impairments .

HY-115498

ARN14494	Apoptosis NO Synthase Interleukin Related COX	Neurological Disease Inflammation/Immunology
ARN14494 is a potent and selective serine palmitoyltransferase (SPT) inhibitor, with an IC₅₀ of 27.3 nM. ARN14494 affects the CNS in terms of anti-inflammation and neuroprotection. ARN14494 protects neurons from β-amyloid 1-42-induced neurotoxicity through a variety of mechanisms, including anti-oxidation, anti-apoptosis, and anti-inflammation. ARN14494 can be used for Alzheimer’s disease research .

HY-N0976

1,11b-Dihydro-11b-hydroxymedicarpin 11b-Hydroxy-11b,1-dihydromedicarpin	Interleukin Related	Inflammation/Immunology
1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative . Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways . Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice .

HY-B0358A

Flunarizine dihydrochloride 3 Publications Verification	Calcium Channel Sodium Channel Dopamine Receptor	Neurological Disease
Flunarizine dihydrochloride is a potent dual Na ⁺/Ca ²⁺ channel (T-type) blocker. Flunarizine dihydrochloride is a D₂ dopamine receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects .

HY-114978

VU0424465	mGluR PERK	Neurological Disease
VU0424465 is a potent and partial PAM (positive allosteric modulator)-agonist for mGlu₅ mediated iCa ²⁺ mobilization. VU0424465 exhibits high affinity at MPEP allosteric binding site, with a K_i value of 11.8 nM. VU0424465 is also a agonist for pERK1/2 in cortical neurons .

[Pro9]-Substance P	Neurokinin Receptor	Neurological Disease
[Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC₅₀ of 0.93 nM .

CGP7930	GABA Receptor	Neurological Disease
CGP7930 (3-(3’,5’-Di-tert-butyl-4’-hydroxy) phenyl-2, 2-dimethylpropanol) is a positive metabotropic GABAB receptor allosteric modulator. CGP7930 enhances the inhibitory effect of l-baclofen on the oscillatory activity of cultured cortical neurons .

3',4'-Dimethoxyflavone	Flavonoids other families Flavones Coniogramme japonica (Thunb.) Diels Plants	PARP Reactive Oxygen Species Aryl Hydrocarbon Receptor
3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects .

Aloin 5+ Cited Publications Aloin-A; Barbaloin-A	Quinones Structural Classification Liliaceae Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Disease Research Fields Cancer	Others
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) .

Paeonilactone B (+)-Paeonilactone B	Structural Classification Natural Products Paeonia lactiflora Pall. Source classification Plants Paeoniaceae	Others
Paeonilactone B is a monoterpene with neuroprotective effect against oxidative stress. Paeonilactone B protects rat cortical cells against H₂O₂-induced neurotoxicity .

5-Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone	Structural Classification Gramineae Source classification Phenols Polyphenols Plants Imperata cylindrica (L.) Beauv.	Others
Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone is a neuroprotective agent . Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone shows significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cell .

Sauristolactam Saurolactam	Alkaloids Monophenols Aristolochia debilis Sieb. et Zucc. Source classification Phenols Plants Aristolochiaceae Indole Alkaloids	Others
Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus chinensis, has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells . Sauristolactam also inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation .

1,11b-Dihydro-11b-hydroxymedicarpin 11b-Hydroxy-11b,1-dihydromedicarpin	Structural Classification Natural Products Classification of Application Fields Leguminosae Source classification Derris robusta Plants Inflammation/Immunology Disease Research Fields	Interleukin Related
1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative . Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways . Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice .

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cortical cells

Inhibitors & Agonists

Peptides

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Natural
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